The metabolite may last longer in the body, up to 82 hours. The mean half-life (or how long it takes for the body to get rid of half of the drug) for clobazam ranges 36 to 42 hours. Clobazam and its main metabolite last a long time in the body. The parent or main drug (clobazam) provides most of the activity in the brain to decrease or stop seizures. Yet the main metabolite can also be active in the brain in smaller amounts. Clobazam is metabolized or broken down in the liver to the parent or main drug and breakdown products called metabolite. The majority of the medicine is bound to proteins as it circulates through the bloodstream. The drug is distributed throughout the body quickly. Taking the medication with or without food doesn't affect how it is absorbed into the body. The amount peaks or reaches its highest level within 30 minutes to 4 hours after a dose is taken. Clobazam is absorbed quickly into the blood stream. Throw away any unused Onfi suspension after this time.

Also, use Onfi oral suspension within 90 days of first opening the bottle.

Make sure to replace the cap securely after opening the oral suspension bottle and keep the bottle upright.

Store the tablets and oral film strips at room temperature in a dry place that is out of the reach of children.

Sympazan can be taken before or after food, just like other forms of clobazam.

If the film strip is swallowed by mistake, the medicine will still be absorbed into your system. Do not use any liquids when you are placing the film on your tongue.Place it on your tongue and let it dissolve.

Open the package and take out the Sympazan film strip.Measure your dose of Onfi oral suspension using the bottle adapter and dosing syringes that are given with the suspension.If you are taking the Onfi oral suspension, shake the bottle well right before you take each dose.Stopping this medicine suddenly can cause seizures that will not stop, hearing or seeing things that are not there, shaking, nervousness, or stomach and muscle cramps. Do NOT stop taking this drug suddenly.Clobazam can be taken with food or without food.They can also be split in half along the score or crushed and mixed with applesauce or another soft food. Clobazam tablets should be swallowed whole, followed by at least a half a glass of water.It takes 5 to 9 days for the dose to reach a stable state in the body. The dose is usually increased once a week or more slowly.For people who weigh more than 30 kg or 66 pounds, the drug is usually started at 10 mg each day.For people who weigh less than 30 kg or 66 pounds, Onfi is usually started at 5 mg per day.The dose of Onfi prescribed and how to increase it may vary with a person's body weight.

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